What is Ollier’s Disease?

What is Ollier’s Disease?

What is Ollier’s Disease

Ollier’s Disease is a rare disorder impacting approximately 1/100,000 persons across the globe. It is classified as a rare disorder.

Ollier disease is a disorder characterized by multiple enchondromas, which are noncancerous (benign) growths of cartilage that develop within the bones that are often noticed when they lead to deformity. These growths most commonly occur in the limb bones, especially in the bones of the hands and feet; however, they may also occur in the skull, ribs, and bones of the spine (vertebrae). Enchondromas tend to develop near the ends of bones and may result in severe bone deformities, shortening of the limbs, and fractures that require intervention.

Although the enchondromas associated with Ollier disease start out as benign and often troublesome, they may become cancerous (malignant). In particular, affected individuals may develop bone cancers called chondrosarcomas, especially in the skull. People with Ollier disease also have an increased risk of other cancers, such as ovarian or liver cancer and it’s recommended that regular monitoring and screening occur.

After puberty, these growths typically stabilize as cartilage is replaced by bone and the disease is often found in children.

The exact cause of Ollier disease is not known, although in some cases it may be inherited as an autosomal dominant genetic trait however, I have yet to find solid research or statistics on this as most of the reporting states that there is no genetic link.

The lifespan for someone with Ollier’s Disease is “normal” with the most important factor being the development of malignancy (1)

Obviously, more research is desperately needed and this website has been developed as a beacon and as a source to gather information and collaborate with other individuals experiencing Ollier’s Disease, caregivers (like myself), Physicians and Therapists.

ollier's disease
By Hellerhoff – Own work, CC BY-SA 3.0 https://commons.wikimedia.org/w/index.php?curid=10322016

 

References:

  1. https://ghr.nlm.nih.gov/condition/ollier-disease
  2. https://rarediseases.info.nih.gov/diseases/7251/ollier-disease
  3. https://rarediseases.org/rare-diseases/ollier-disease/


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